Potential of Sechium edule as Hypertensive Therapy: In Silico Study

Maria Marcelina Dua Nurak, Maria Alvensia Lute, Margaretha Nona Eci, Yohanes Bare

Abstract


Hipertensi didefinisikan sebagai tekanan darah tinggi dan menjadi salah satu pembunuh di dunia. Terapi hipertensi berfokus pada protein Angiotensin Converting Enzim (ACE) yang memiliki fungsi modulator konversi AT1-AT2. Pengobatan memanfaatkan kandungan kalium buah labu yang memiliki fungsi supresi ACE. Tujuan penelitian ini eksplorasi kalium dalam labu siam sebagai inhibitor ACE. Penelitian bioinformatika, kalium (CID: 5462222) diunduh dari database PubChem sedangkan protein ACE (ID: 3bkk) diperoleh dari Protein Data Bank. Ligan dan protein didocking menggunakan perangkat lunak HEX, hasil penelitian divisualisasikan menggunakan Discovery studio. Hasil penelitian menunjukan bahwa labu siam memiliki kandungan kalium yang memiliki potensi sebagai salah satu terapi hipertensi melalui penghambatan kinerja ACE sehingga tidak terjadi konversi angiotensin I menjadi angiotensin II. Labu siam dapat dijadikan alternatif dalam pengobatan hipertensi. 


Keywords


ACE, hipertensi, kalium, labu siam

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References


Ahmad, N. I., Bunga, Y. N., & Bare, Y. (2019). Etnobotani Tanaman Cabai Merah Keriting (Capsicum Annum L.) Di Desa Waiwuring, Kecamatan Witihama Kabupaten Flores Timur. Spizaetus: Jurnal Biologi dan Pendidikan Biologi, 2(2), 10.

Bare, Y. (2022). Interaction Phloroglucinol as inflammation therapy through Cyclooxygenase-2 (COX-2) gene inhibition. Jurnal Ilmiah Medicamento, 8(1), 14–21. https://doi.org/10.36733/medicamento.v8i1.3162

Bare, Y., Helvina, M., Krisnamurti, G. C., & S, M. (2020). The Potential Role of 6-gingerol and 6-shogaol as ACE Inhibitors in Silico Study. Biogenesis: Jurnal Ilmiah Biologi, 8(2), 210. https://doi.org/10.24252/bio.v8i2.15704

Bare, Y., Sari, D. R., Rachmad, Y. T., Tiring, S. S. N. D., Rophi, A. H., & Nugraha, F. A. D. (2019). Prediction Potential Chlorogenic Acid As Inhibitor Ace (In Silico Study). Bioscience, 3(2), 197. https://doi.org/10.24036/0201932105856-0-00

Bare, Y., & Sari, D. R. T. (2021). Pengembangan Lembar Kerja Mahasiswa (LKM) Berbasis Inkuiri Pada Materi Interaksi Molekuler. BioEdUIN, 11(1), 8. https://doi.org/10.15575/bioeduin.v11i1.12077

Bare, Y., Sari, D. R. T., Ujiana, W. O., Ra’o, P. Y. S., & Pada, K. (2022). REPURPOSING OF 6-PARADOL AS AN ALTERNATIVE HERBAL MEDICINE FOR ALZHEIMER DISEASE. Medical Sains : Jurnal Ilmiah Kefarmasian, 7(2), 1–8. https://doi.org/10.37874/ms.v7i2.289

Bhullar, K. S., Lassalle-Claux, G., Touaibia, M., & Rupasinghe, H. P. V. (2014). Antihypertensive effect of caffeic acid and its analogs through dual renin–angiotensin–aldosterone system inhibition. European Journal of Pharmacology, 730, 125–132. https://doi.org/10.1016/j.ejphar.2014.02.038

Bloch, M. J. (2016). Worldwide prevalence of hypertension exceeds 1.3 billion. Journal of the American Society of Hypertension, 10(10), 753–754. https://doi.org/10.1016/j.jash.2016.08.006

Chiou, S.-Y., Sung, J.-M., Huang, P.-W., & Lin, S.-D. (2017). Antioxidant, Antidiabetic, and Antihypertensive Properties of Echinacea purpurea Flower Extract and Caffeic Acid Derivatives Using In Vitro Models. Journal of Medicinal Food, 20(2), 171–179. https://doi.org/10.1089/jmf.2016.3790

Elfi, T. N., Bunga, Y. N., & Bare, Y. (2021). Studi Aktivitas Biologi Secara In Silico Senyawa Nonivamide Dan Nordihydrocapsaicin Sebagai Anti Inflamasi. Florea : Jurnal Biologi dan Pembelajarannya, 8(2), 82. https://doi.org/10.25273/florea.v8i2.9983

Ferrario, C. M. (2011). ACE2: More of Ang-(1–7) or less Ang II?: Current Opinion in Nephrology and Hypertension, 20(1), 1–6. https://doi.org/10.1097/MNH.0b013e3283406f57

Gunawan, D. (2012). Ilmu Obat Alam (Farmakologi) Jilid I. Penebar Swadaya.

Imai, Y., Kuba, K., & Penninger, J. M. (2008). The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice: Discovery of ACE2 and its role in acute lung injury. Experimental Physiology, 93(5), 543–548. https://doi.org/10.1113/expphysiol.2007.040048

KEMENKES. (2018). Hasil Utama RESKESDAS 2018. Kementrian Kesehatan Badan Penelitian dan Pengembangan Kesehatan.

Krisnamurti, G. C., Bare, Y., Amin, M., & Primiani, C. N. (2020). Combination of Curcumin from Curcuma longa and Procyanidin from Tamarindus indica in Inhibiting Cyclooxygenases for Primary Dysmenorrhea Therapy: In silico study. Biointerface Research in Applied Chemistry, 11(1), 7460–7467. https://doi.org/10.33263/BRIAC111.74607467

Krisnamurti, G. C., Sari, D. R. T., & Bare, Y. (2021). Capsaicinoids from Capsicum annuum as an Alternative FabH Inhibitor of Mycobacterium Tuberculosis: In Silico Study. Bahan Alam, COX-2, Inflamasi, Phaeophyta, Phloroglucinol, 25(4), 195–202. https://doi.org/10.7454/mss.v25i4.1248

Lalage, Z. (2013). Khasiat Selangit 101 Buah dan Sayur. Galmas Publisher.

Sari, D. R. T., Krisnamurti, G. C., & Bare, Y. (2022). Pemetaan Bioaktivitas Senyawa Metabolit Sekunder Pada Kayu Secang (Caesalpinia sappan) Secara In Silico. Journal Pharmasci (Journal of Pharmacy and Science), 7(1), 8.

Vincentius, A., & Bare, Y. (2022). Pemetaan Bioaktivitas Senyawa pada Kantung Tinta Cumi-cumi (Loligo vulgaris) Secara In Silico. Jurnal Ilmiah Wahana Pendidikan, 8(2), 09–16. https://doi.org/10.5281/ZENODO.5971402

WHO. (2013). A global brief on hypertension: Silent killer, global public health crisis: World Health Day 2013. WHO Press.

Williamson, C. R., Khurana, S., Nguyen, P., Byrne, C. J., & Tai, T. C. (2017). Comparative Analysis of Renin-Angiotensin System (RAS)-Related Gene Expression Between Hypertensive and Normotensive Rats. Medical Science Monitor Basic Research, 23, 20–24. https://doi.org/10.12659/MSMBR.901964




DOI: http://dx.doi.org/10.55241/spibio.v3i2.60

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